SYNTHESIS AND ANTIMICROBIAL ACTIVITY OF NEW 3,5-DIAMINOISOTHIAZOLE DERIVATIVES

Authors
COCCO MT CONGIU C MACCIONI A ONNIS V SCHIVO ML DELOGU A
Citation
Mt. Cocco et al., SYNTHESIS AND ANTIMICROBIAL ACTIVITY OF NEW 3,5-DIAMINOISOTHIAZOLE DERIVATIVES, Il Farmaco, 49(2), 1994, pp. 137-140
Citations number
15
Categorie Soggetti
Pharmacology & Pharmacy
Journal title
Il Farmaco → ACNP
ISSN journal
0014827X
Volume
49
Issue
2
Year of publication
1994
Pages
137 - 140
Database
ISI
SICI code
0014-827X(1994)49:2<137:SAAAON>2.0.ZU;2-P
Abstract
The 3,5-diaminoisothiazole derivatives 23-42 were synthesized in excel lent yields by oxidative cyclization of 3-amino-3-(dialkylamino)propen ethioamide derivatives. These intermediates and the isothiazole deriva tives were tested in vitro for their antimicrobial activity.