ALKYL ETHER ANALOGS OF THE FK-506 RELATED, IMMUNOSUPPRESSIVE MACROLIDE L-683,590 (ASCOMYCIN)

Authors
GOULET MT HODKEY DW STARUCH MJ DUMONT FJ CRYAN JG PARSONS WH WYVRATT MJ
Citation
Mt. Goulet et al., ALKYL ETHER ANALOGS OF THE FK-506 RELATED, IMMUNOSUPPRESSIVE MACROLIDE L-683,590 (ASCOMYCIN), Bioorganic & medicinal chemistry letters, 4(7), 1994, pp. 921-926
Citations number
26
Categorie Soggetti
Chemistry Inorganic & Nuclear","Chemistry Medicinal
Journal title
Bioorganic & medicinal chemistry letters → ACNP
ISSN journal
0960894X
Volume
4
Issue
7
Year of publication
1994
Pages
921 - 926
Database
ISI
SICI code
0960-894X(1994)4:7<921:AEAOTF>2.0.ZU;2-V
Abstract
C32-O-Ether derivatives of L-683,590 have been prepared by alkylation with various alkyl, alkenyl, and alkynyl 2,2,2-trichloroacetimidates. These analogs exhibit good immunosuppressive activity in vitro, as mea sured in a T cell proliferation assay. In the case of cinnamyl ethers, this activity correlates with the lipophilicity (pi value) of the aro matic substituents.