INHIBITION OF SOLUBLE CATECHOL-O-METHYLTRANSFERASE AND SINGLE-DOSE PHARMACOKINETICS AFTER ORAL AND INTRAVENOUS ADMINISTRATION OF ENTACAPONE

Authors
KERANEN T GORDIN A KARLSSON M KORPELA K PENTIKAINEN PJ RITA H SCHULTZ E SEPPALA L WIKBERG T
Citation
T. Keranen et al., INHIBITION OF SOLUBLE CATECHOL-O-METHYLTRANSFERASE AND SINGLE-DOSE PHARMACOKINETICS AFTER ORAL AND INTRAVENOUS ADMINISTRATION OF ENTACAPONE, European Journal of Clinical Pharmacology, 46(2), 1994, pp. 151-157
Citations number
30
Categorie Soggetti
Pharmacology & Pharmacy
Journal title
European Journal of Clinical Pharmacology → ACNP
ISSN journal
00316970
Volume
46
Issue
2
Year of publication
1994
Pages
151 - 157
Database
ISI
SICI code
0031-6970(1994)46:2<151:IOSCAS>2.0.ZU;2-A
Abstract
The inhibition of soluble catechol-O-methyl-transferase (S-COMT) in re d blood cells (RB Cs) by entacapone, and the pharmacokinetics of entac apone after single oral (5-800 mg) and IV (25 mg) doses have been exam ined in an open study in 12 healthy young male volunteers.