Rd. Mattes et al., EFFECTS OF CANNABINOIDS (MARIJUANA) ON TASTE INTENSITY AND HEDONIC RATINGS AND SALIVARY FLOW OF ADULTS, Chemical senses, 19(2), 1994, pp. 125-140
Cannabinoids purportedly improve taste responsiveness and enhance the
sensory appeal of foods. These properties and a commonly cited oral dr
ying effect were evaluated in a series of studies with 'light' marijua
na users. The first was a double-blind, placebo-controlled, acute oral
dosing trial, involving an age and gender stratified sample of 57 adu
lts. An influence of route of drug delivery was explored in another 11
individuals who were administered a single dose orally, sublingually
and via cigarette. To explore effects following chronic administration
, six additional individuals were dosed twice per dap for 3 days orall
y and by rectal suppository. Taste intensity and hedonic responses for
sweet, sour, salty and bitter food stimuli were monitored at baseline
, 2, 4 and 6 hours post-dosing in the acute studies, and daily in the
chronic study. Stimulated saliva samples were collected at these same
times. Salivary now rate was significantly negatively correlated with
plasma drug levels, and reported 'high' 2 and 4 h post-dosing. No effe
cts of the drug were observed on taste responses. Self-reported shifts
in taste responsiveness and hedonics may be related to alterations of
memory and cognition, rather than gustatory function.