STABILITY OF SULFAQUINOXALINE, SULFADIMETHOXINE, AND THEIR N-4-ACETYLDERIVATIVES IN CHICKEN TISSUES DURING FROZEN STORAGE

The N-4-acetyl derivatives of sulfaquinoxaline and sulfadimethoxine we re stable in fortified chicken liver and thigh muscle tissues during f rozen storage for 1 year at -20 and -70 degrees C. In contrast, the pa rent compounds depleted approximately 35% in liver tissues at -20 degr ees C. The transformation of the depleted sulfa drugs to their n(4)-gl ucopyranosyl derivatives was negligible, suggesting that products othe r than glucosides resulted during the storage period.