DIAGNOSTIC SPECIFICITY OF ANTINEUTROPHIL CYTOPLASMIC ANTIBODIES (ANCA) IN OTORHINOLARYNGOLOGICAL DISEASES

The incidence and titer of ANCA were examined with 871 sera from patie nts with otorhinolaryngological diseases at our hospital. The cytoplas mic pattern of ANCA (c-ANCA) whose titer was more than 16 was detected only in the sera of patients with Wegener's granulomatosis (WG). The incidence of c-ANCA in active WG was more than 90%. The perinuclear st aining pattern of ANCA (p-ANCA) was detected in almost 40% of patients with Sjogren's syndrome, 2.0% of inflammatory diseases and 1.0% of tu morous diseases. A high diagnostic value of c-ANCA in WG was found in patients with otorhinolaryngological diseases.