Rw. Mays et al., ORGANIZATION AND FUNCTION OF THE CYTOSKELETON IN POLARIZED EPITHELIAL-CELLS - A COMPONENT OF THE PROTEIN SORTING MACHINERY, Current opinion in cell biology, 6(1), 1994, pp. 16-24
Development and maintenance of cell-surface polarity in epithelial cel
ls requires specialized localization of proteins to functionally and s
tructurally distinct plasma membrane domains. The organization of thes
e domains is dependent upon targeted delivery of transport vesicles be
tween different membrane compartments, and upon protein sorting in the
membranes of the Golgi complex and cell surface. Increasing evidence
has been gathered in recent years that cytoskeletal components facilit
ate these processes.