MONO-N-ALKYLATION OF ANTHRANILAMIDES VIA QUINAZOLINONES - AN EFFICIENT SYNTHESIS OF G5598, A BENZODIAZEPINE DIONE GPIIBIIIA ANTAGONIST

Authors
WEBB RR BARKER PL BAIER M REYNOLDS ME ROBARGE KD BLACKBURN BK TISCHLER MH WEESE KJ
Citation
Rr. Webb et al., MONO-N-ALKYLATION OF ANTHRANILAMIDES VIA QUINAZOLINONES - AN EFFICIENT SYNTHESIS OF G5598, A BENZODIAZEPINE DIONE GPIIBIIIA ANTAGONIST, Tetrahedron letters, 35(14), 1994, pp. 2113-2116
Citations number
12
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Tetrahedron letters → ACNP
ISSN journal
00404039
Volume
35
Issue
14
Year of publication
1994
Pages
2113 - 2116
Database
ISI
SICI code
0040-4039(1994)35:14<2113:MOAVQ->2.0.ZU;2-G
Abstract
The mono-N-alkylation of an anthranilamide derivative via the reductiv e ring opening of a quinazolinone precursor, enables the synthesis of benzodiazepine dione derivative G5598, a potent inhibitor of the in vi tro binding of GpIIbIIIa to fibrinogen.