RA-III LACTONE, A 19-MEMBERED RING ANALOG OF RAS, ANTITUMOR CYCLIC HEXAPEPTIDE

Authors
HITOTSUYANAGI Y KONDO K TAKEYA K ITOKAWA H
Citation
Y. Hitotsuyanagi et al., RA-III LACTONE, A 19-MEMBERED RING ANALOG OF RAS, ANTITUMOR CYCLIC HEXAPEPTIDE, Tetrahedron letters, 35(14), 1994, pp. 2191-2194
Citations number
19
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Tetrahedron letters → ACNP
ISSN journal
00404039
Volume
35
Issue
14
Year of publication
1994
Pages
2191 - 2194
Database
ISI
SICI code
0040-4039(1994)35:14<2191:RLA1RA>2.0.ZU;2-H
Abstract
Antitumor cyclic hexapeptide RA-III (2) has been converted to a lacton e analogue 3 which is the first analogue of RAs in which the 18-member ed macro ring was modified. 3 was found to possess promising antitumor activity, and its solution conformation was established by NMR spectr oscopy.