CELLULAR AND MOLECULAR ABNORMALITIES IN THE VASCULAR ENDOTHELIUM OF DIABETES-MELLITUS

Authors
KING GL SHIBA T OLIVER J INOGUCHI T BURSELL SE
Citation
Gl. King et al., CELLULAR AND MOLECULAR ABNORMALITIES IN THE VASCULAR ENDOTHELIUM OF DIABETES-MELLITUS, Annual review of medicine, 45, 1994, pp. 179-188
Citations number
40
Categorie Soggetti
Medicine, General & Internal
Journal title
Annual review of medicine → ACNP
ISSN journal
00664219
Volume
45
Year of publication
1994
Pages
179 - 188
Database
ISI
SICI code
0066-4219(1994)45:<179:CAMAIT>2.0.ZU;2-7
Abstract
Diabetic vascular complications affect both micro- and macrovasculatur e, primarily in the retina, renal glomeruli, and multiple sites in the macrovessels. This review presents a summary of the abnormal function found in vivo and in cultured vascular cells exposed to elevated leve ls of glucose. We also discuss the various biochemical hypotheses that have been proposed to explain the adverse effects of hyperglycemia on vascular cells.