INTERFERONS IN THE TREATMENT OF ADVANCED BREAST-CANCER

In the past two decades interferons have undergone extensive phase I a nd II evaluations in various types of cancers, including breast cancer . This article reviews the experience, obtained from preclinical and c linical studies, about the clinical rationale efficacy and toxicity of interferons in cancer treatment In particular, we examine the preclin ical experience in which antineoplastic activity of interferon against breast cancer has been demonstrated Finally we discuss clinical data accumulated using interferon-alpha, interferon-beta and lymphoblastoid interferon alone or in combination in metastatic breast cancer patien ts. The use of the interferons in the treatment of breast cancer remai ns investigational and the optimal scheduling undetermined. New method s of administration may maximize the antitumor effects in order to bet ter understand the role of interferon in clinical oncology.