A patient with diffuse osteoblastic metastases from Invasive lobular c
arcinoma of the breast is presented in whom radionuclide bone scan was
negative for skeletal lesions. Skeletal metastases were documented by
plain radiography, CT, MRI, and bone marrow biopsy. This case report
points to the value of plain-film, CT, and MRI findings in situations
of high clinical suspicion of metastatic disease despite a normal scin
tigraphy.