SYNTHESIS AND STRUCTURES OF SOME DIORGANOTIN BIS(HYDROXAMATE)S

Analysis of literature data on the antitumor activity of organotin com pounds reveals that R2SnX2 and their complexes containing Sn-O, Sn-N o r Sn-S bonds often exhibit biological activity, especially if such bon ds are formed by means of intramolecular coordination. Furthermore, a wide range of biological activities, from fungicidal, bactericidal and antiseptic to psychotropic and antitumor, is found to be characterist ic for some organic hydroxamic acids (N-acylhydroxylamines). From this point of view the diorganotin bis-hydroxamates in this paper are of p articular interest as potential biologically active antitumor drugs. D i-n-butyltin bis(N-methyl-N-p-bromobenzoylhydroxylamine) is being scre ened for antitumor activity.