EXPERIMENTALLY-INDUCED MALIGNANT-LYMPHOMA DUE TO CHRONIC ANTIGEN STIMULATION

Animal experiments were started in 1988 with the aim of inducing malig nant lymphomas. 52 guinea pigs were exposed to potassium dichromate us ing the TINA test (plus 39 control animals). Following the sensitizati on procedure, the test animals and, 15 control guinea pigs were expose d daily (5 x a week) epicutaneously to the antigen up to the present t ime. Currently, 30 exposed and 17 control animals are still in the exp eriment. In 3 out of 17 post-mortem examinations, histologically evide nt lymphomas were found. In the control animals, no tumor has been see n. The experiments support lymphoma causation by chronic antigen stimu lation. The experiments are continuing. (C) Munksgaard, 1994.