A. Malafosse et al., BENIGN INFANTILE FAMILIAL CONVULSIONS ARE NOT AN ALLELIC FORM OF THE BENIGN FAMILIAL NEONATAL CONVULSIONS GENE, Annals of neurology, 35(4), 1994, pp. 479-482
Benign infantile familial convulsions (BIFC) and benign familial neona
tal convulsions (BFNC) are two forms of familial convulsions having an
age of onset within the first year of life. The gene responsible for
BFNC has been mapped to chromosome 20q in the close vicinity of D20S19
and D20S20 markers. We performed linkage analysis between BIFC and D2
0S19-D20S20 in eight families in order to know whether the BFNC gene i
s also implicated in BIPC. Several apparent obligate crossovers betwee
n affected members were detected. The data here presented demonstrate
that the BFNC gene is not responsible for BIPC.