CALPEPTIN, A CALPAIN INHIBITOR, PROMOTES NEURITE ELONGATION IN DIFFERENTIATING PC12 CELLS

Authors
PINTER M ASZODI A FRIEDRICH P GINZBURG I
Citation
M. Pinter et al., CALPEPTIN, A CALPAIN INHIBITOR, PROMOTES NEURITE ELONGATION IN DIFFERENTIATING PC12 CELLS, Neuroscience letters, 170(1), 1994, pp. 91-93
Citations number
8
Categorie Soggetti
Neurosciences
Journal title
Neuroscience letters → ACNP
ISSN journal
03043940
Volume
170
Issue
1
Year of publication
1994
Pages
91 - 93
Database
ISI
SICI code
0304-3940(1994)170:1<91:CACIPN>2.0.ZU;2-E
Abstract
Calpain activity of nerve growth factor (NGF)-induced rat pheochromocy toma (PC12) cells shows a transient diminution in the early phase of d ifferentiation. Calpain activity can be further decreased by a cell-pe rmeable calpain inhibitor, calpeptin, which enhances the effect of NGF by stimulating neurite elongation. The number of neurites sprouted by one cell is not increased by calpeptin. A possible role of calpain in hibition during PC12 cells' early differentiation is discussed.