GENETIC STABILITY OF MICROSATELLITES IN HUMAN NEUROBLASTOMAS

Authors
GEHRING M BERTHOLD F SCHWAB M AMLER L
Citation
M. Gehring et al., GENETIC STABILITY OF MICROSATELLITES IN HUMAN NEUROBLASTOMAS, International journal of oncology, 4(5), 1994, pp. 1043-1045
Citations number
24
Categorie Soggetti
Oncology
Journal title
International journal of oncology → ACNP
ISSN journal
10196439
Volume
4
Issue
5
Year of publication
1994
Pages
1043 - 1045
Database
ISI
SICI code
1019-6439(1994)4:5<1043:GSOMIH>2.0.ZU;2-9
Abstract
Genetic instability resulting from deficiency in replication error rep air (RER) has been detected in a variety of human cancers. We have exa mined the stability of five 1p microsatellites in 51 human neuroblasto mas including stages 1, 2, 3, 4 and 4s. None of the tumors showed an a berrant pattern indicating RER at any microsatellite. Our results do n ot support a major role for increased genetic instability as the resul t of deficient replication error repair in neuroblastoma.