CONCURRENT INVASIVE THYMOMA AND T-CELL LYMPHOBLASTIC-LEUKEMIA AND LYMPHOMA - A CASE-REPORT WITH NECROPSY FINDINGS AND LITERATURE-REVIEW OF THYMOMA AND ASSOCIATED HEMATOLOGIC NEOPLASM

Thymoma is associated with benign and neoplastic diseases. The authors report the concurrence of invasive thymoma and T-lymphoblastic leukem ia/lymphoma in a 95-year-old man. The hematologic malignancy was suspe cted terminally, whereas the thymoma was discovered at necropsy. The l ymphoblastic leukemia/lymphoma had a clonally rearranged T-cell recept or beta-chain gene and a mature thymocyte immunophenotype. No retrovir al gene sequences (human immunodeficiency virus 1 and 2, and human T-c ell leukemia virus 1 and 2) were identified by polymerase chain reacti on and hybridization analysis. The association of thymoma with hematol ogic neoplasm is reviewed.