ELECTROPHYSIOLOGICAL AND FIELD ACTIVITY OF HALOGENATED ANALOGS OF (E,E)-8,10-DODECADIEN-1-OL, THE MAIN PHEROMONE COMPONENT, IN CODLING-MOTH(CYDIA-POMONELLA L)

Pest monitoring and control of the codling moth, Cydia pomonella L., h ave been developed using the main pheromone component of this species, (E,E)-8,10-dodecadienol (codlemone). However, the activity of codlemo ne is not satisfactory for pest control by mating disruption. Thus, we have synthesized halogenated analogs of codlemone to see if they coul d be used as new agents for pest control of the codling moth. Their bi ological activity was measured by electrophysiological techniques. In EAG screening, codlemone was the most active compound. F(10,11)-codlem one [(E,E)-10,11-difluoro-8,10-dodecadienol] and Cl-codlemone [(E,E)-1 1-chloro-8,10-undecadienol] elicited significant EAG responses, F(10,1 1)-codlemone triggering responses not significantly different from res ponses to codlemone. EAG cross-adaptation experiments and single sensi llum recordings revealed that these compounds were detected by the sam e receptor neuron type as codlemone. No competitive inhibition with co dlemone was observed from nonactive compounds. In field trapping, F(10 ,11)-codlemone and Cl-codlemone were more attractive to male codling m oths than codlemone itself. Possible explanations of this activity are discussed.