OBJECTIVE - Many of the ''antiseptic'' practices recommended by health
care professionals for insulin injection have been successfully chall
enged as unnecessary Since people with diabetes have long been observe
d to inject their insulin through their clothing, this study was under
taken to determine the safety and perceived benefits of administering
insulin by this ''rogue'' technique. RESEARCH DESIGN AND METHODS - Fif
ty people with insulin-treated diabetes were randomized into a 20-week
single-blinded prospective crossover study comparing the conventional
subcutaneous injection technique (with skin preparation) to an experi
mental injection technique through clothing. Skin assessment, glycated
hemoglobin levels, and leukocyte count were determined before randomi
zation, at 10 weeks (before crossover), and again at 20 weeks (at comp
letion). The participants injected through a single layer of fabric, w
hich ranged from nylon to denim. Problems, benefits, type of clothing,
and other comments were recorded by the subjects in an injection log.
RESULTS - Forty-two (84%) subjects completed the study. The mean age
was 41 years (range, 23-63 years), 50% were women, 86% were Caucasian,
and 80% had type I diabetes. The mean duration of diabetes was 14 yea
rs (range, 1-33 years). Fifty-one percent had >16 years of education.
The demographic characteristics of thr dropouts were similar to those
who completed the study. Over the 20-week period similar to 13,720 inj
ections were performed by participants. None of the subjects experienc
ed erythema, induration, or abscess at injection sites. Neither the gl
ycated hemoglobin levels nor the leukocyte counts differed between the
conventional and experimental regimens. During the injection-through-
clothing phase of the study only minor problems, such as blood stains
on clothing and bruising, were recorded in the logbooks. However, subj
ects reported that injection through clothing offered benefits such as
convenience and sating time. CONCLUSIONS - It is safe and convenient
to inject insulin through clothing.