EFFECTS OF PROLONGED FENBUTOL ADMINISTRAT ION ON LIPID-METABOLISM IN PATIENTS WITH CORONARY HEART-DISEASE

The investigations have shown that the synthetic antioxidant fenbutol can be classified as one of the drugs that are effective in reducing c holesterol levels in patients with Types IIa and IIb hypercholesterole mia and a good subjective tolerance. The use of the drug along with an adequate hypolipidemic diet caused a significant decrease in total ch olesterol at month 3 of therapy (on an average by 23.7 %) and atheroge nic low density lipoproteins (on an average by 24.6 %). The level of h igh density lipoproteins was decreased on an average by 18.8 %. The le vel of plasma triglycerides was changed to a lesser extent (a 13.8 % d ecrease). The controls who took placebo showed no significant changes in lipid metabolism.