MICROCIRCULATORY CHANGES IN PATIENTS WITH HYPERTENSIVE DISEASE DUE TOEXCESSIVELY LOWERED BLOOD-PRESSURE AFTER CLOFELIN ADMINISTRATION

In 20 patients with Stage II hypertensive disease, erythrocyte and pla telet aggregation to response to ATP was photooptically studied, skin oxygen tension was polarographically examined, and the diameters of co njunctival vessels were microscopically measured. In the patients, exc essive decreases in blood pressure were found to lead to lack of micro vascular tone coordination, to increases in platelet oxygen erythrocyt e aggregation and to decreases in tissue oxygen supply. It was emphasi zed that the microcirculation and tissue oxygen supply should be monit ored when clofelin dosages are chosen individually in the treatment of hypertensive disease.