ALTERATIONS IN PLATELET FUNCTIONAL-ACTIVI TY IN PATIENTS WITH ANGINA-PECTORIS DURING COLD TEST

The functional activity of platelets was examined in patients with cor onary heart disease and healthy individuals during cold test (CT). Pat ients prone to vasospastic responses to CT exhibited platelet activati on along with beta-thromboglobulin release and formation of spontaneou s platelet aggregates. Comparison of functional changes in platelet fu nctional activity which occurred during cold test and intravenous ergo metrine test suggest that the response to CT may be substantially high er if platelet aggregability is concurrently determined. The unidirect ional changes in platelet aggregability during cold and ergometrine te sts in patients with signs of dynamic coronary occlusion may indicate a relation of platelets with coronary vasoconstriction.