TICLOPIDINE AND ASPIRIN IN UNSTABLE ANGIN A - COMPARISON OF DISAGGREGATORY PROPERTIES AND EFFECTS ON PLATELET MEMBRANES

The study was undertaken to examine changes in ADP-induced aggregation of platelets, blood-circulating platelet aggregates, platelet phospho lipids and cholesterol in patients with unstable angina depending on t he therapy with disaggregatory agents. The patients from Group 1 (n=23 ) received ticlopidine, 500 mg/day, in addition to antianginal therapy and heparin; those from Group 2 (n=21) had aspirin, 320 mg/day, those from Group 3 (n=36) took no disaggregahts. Ticlopidine was found to p roduce more marked effects on ADT-induced plasma platelet aggregation, in vivo reversible platelet aggregation, and reduced platelet levels of free cholesterol, as compared to aspirin.