PHARMACOGENETIC APPROACH TO OPTIMIZATION OF BETA-ADRENOBLOCKER THERAPY FOR HYPERTENSIVE DISEASE

A relationship between individual variations of the oxidative and acet ylating metabolism rates of penbutolol, propranolol, acebutol which pr oduce a hypotensive effect was studied in patients with arterial hyper tension. A study was performed in groups of patients, which comprised 22, 22, and 20 males, respectively. They all sufferred from Stage II h ypertensive disease. There was a predominant number of patients with p artial and complete antihypertensive benefits in those with low oxidat ion rates than in those with high oxidative metabolism rates when penb utolol (89 and 54 %, respestively; p<0.05) and propranolol (78 and 31 %, respestively; p<0,01) were given. A graphic analysis of changes in blood pressure, which had been observed during a course monotherapy wi th penbutolol and propranolol identified two groups of patients differ ing in having benefits. Within each group, the relationship between th e decrease in diastolic blood pressure to the elimination half-life of parmidine is described by a linear regression equation and it has a h igh positive correlation coefficient.