INTERACTION OF MAJOR SYSTEMIC HEMODYNAMIC PARAMETERS IN THE ARTERIAL AND VENOUS REGIONS IN THE USE OF NIFEDIPINE AND VERAPAMIL

Electromagnetic flowmetry and analogue computers were used to evaluate changes in great venous and arterial blood flow and resistance altera tions in the vesells after nifedipine and verapamil in experiments wit h 12 anesthesized cats. The agents were demonstrated to increase cardi ac output due to lower afterload and venous return, to redistribute ca rdiac output towards greater brain blood supply. The latter was caused by a more marked decrease in vascular resistance in the brachiocephal ic arterial tree than in the descending thoracic artery. Blood flow ch anges in the great arteries determined those in the vena cava superior and inferior.