Objective: This review will include the general pharmacology of lithiu
m and discuss its effects on various organ systems, with emphasis on t
he medically ill patient as well as the geriatric patient with multipl
e medical problems. Methods: A full literature review on the side effe
cts of lithium was performed Attention is focused on the medically ill
and possible drug interactions. Results: This review points to the nu
merous problems which can result in toxicity in the medically ill or t
he geriatric patient. Conclusion: Serious side effects can be avoided
with proper drug monitoring and knowledge of potential drug interactio
ns.