POLY(ADP-RIBOSE) POLYMERASE - A MOLECULAR NICK-SENSOR

Authors
DEMURCIA G DEMURCIA JM
Citation
G. Demurcia et Jm. Demurcia, POLY(ADP-RIBOSE) POLYMERASE - A MOLECULAR NICK-SENSOR, Trends in biochemical sciences, 19(4), 1994, pp. 172-176
Citations number
36
Categorie Soggetti
Biology
Journal title
Trends in biochemical sciences → ACNP
ISSN journal
09680004
Volume
19
Issue
4
Year of publication
1994
Pages
172 - 176
Database
ISI
SICI code
0968-0004(1994)19:4<172:PP-AMN>2.0.ZU;2-S
Abstract
Poly(ADP-ribose) polymerase (PARP) participates in the intricate netwo rk of systems developed by the eukaryotic cell to cope with the numero us environmental and endogenous genotoxic agents. Cloning of the PARP gene has allowed the development of genetic and molecular approaches t o elucidate the structure and function of this abundant and highly con served enzyme.