DNAJ-LIKE PROTEINS - MOLECULAR CHAPERONES AND SPECIFIC REGULATORS OF HSP70

The folding of proteins and the assembly of protein complexes within s ubcompartments of the eukaryotic cell is catalysed by different member s of the Hsp70 protein family. The chaperone function of Hsp70 protein s in these events is regulated by members of the DnaJ-like protein fam ily, which occurs through direct interaction of different Hsp70 and Dn aJ-like protein pairs that appear to be specifically adapted to each o ther. This review highlights the diversity of functions of DnaJ-like p roteins by using specific examples of DnaJ-Hsp70 interactions with pol ypeptides in yeast protein-biogenesis pathways.