LIPASE-CATALYZED RESOLUTION OF GLYCEROL 2,3-CARBONATE

Authors
PALLAVICINI M VALOTI E VILLA L PICCOLO O
Citation
M. Pallavicini et al., LIPASE-CATALYZED RESOLUTION OF GLYCEROL 2,3-CARBONATE, Journal of organic chemistry, 59(7), 1994, pp. 1751-1754
Citations number
16
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Journal of organic chemistry → ACNP
ISSN journal
00223263
Volume
59
Issue
7
Year of publication
1994
Pages
1751 - 1754
Database
ISI
SICI code
0022-3263(1994)59:7<1751:LROG2>2.0.ZU;2-P
Abstract
Glycerol 2,3-carbonate was resolved via Pseudomonas fluorescens lipase catalyzed acetylation of the racemate and subsequent alcoholysis of t he optically enriched acetate product in the presence of the same enzy me. The two reactions, performed in CHCl3, gave (R)- and (S)-glycerol 2,3-carbonate respectively in high chemical and optical yields.