All new attenders at the Menopause Clinic in Edinburgh over six months
were interviewed to detect current depressive disorder (MADRS) and pa
st psychiatric disorders (SADS-L), to find out whether women who were
depressed at the time of clinic attendance had a history of depression
. Of the 95 subjects who entered the study, 78 had gone through a natu
ral menopause and 17 had undergone hysterectomy with or without oophor
ectomy. Of the 78 who had experienced a natural menopause, 35 were fou
nd to be depressed at the time of clinic attendance and 43 were not. A
strong association was found between current and past depressive illn
ess, 29 of the patients depressed at the time of clinic attendance hav
ing had depression previously. However, a clear peak of illness was se
en in the perimenopausal period (four years either side of the last me
nstrual period): 35% of all patients with past or current depressive i
llness experienced their first episode of illness in this period.