AN AUTOPSY CASE OF BINSWANGER-DISEASE WITHOUT HYPERTENSION AND ASSOCIATED WITH CEREBRAL INFARCTION IN THE TERMINAL STAGE

We report here an autopsy case of Binswanger's disease (BD) without hy pertension and associated with cerebral infarction in the terminal sta ge. The female patient, who was 74 years old at the time of death, had initially demonstrated manic-depressive disorder-like mental disorder , followed by dementia and neurological deficits. A brain CT scan show ed white matter low attenuation bilaterally and symmetrically. BD was clinically diagnosed despite the lack of hypertension. In the terminal stage, she suffered an infarction in the left anterior cerebral arter y region, and died of pneumonia. Neuropathologically, we found the inf arction of the left anterior cerebral artery region, demyelination, fi brillary gliosis, lacunae and arteriosclerosis of the small arteries a nd arterioles in the white matter.