It has been classically hypothesized that a mass in the nasopharynx ca
uses an obstacle to air flow through the eustachian tube, thereby crea
ting a negative pressure in the middle ear followed by an effusion. Ho
wever, examination of the relevant data concerning the supposed obstru
ction of the eustachian tube by nasopharyngeal carcinomas, choanal pol
yps and adenoids does not seem to support this cause and effect relati
onship. Evidence points to other more sophisticated mechanisms which c
ause negative pressure and an effusion in pathological middle ear cond
itions. While the hypothesis of a nasopharyngeal mass as the usual obs
tructive cause of middle ear effusion is hard to maintain, evidence do
es exist to support the origin of middle ear infection, as seen in acu
te and secretory otitis media, as being associated, at times, with an
ascending infection from the nasopharynx.