A NOVEL 3-COMPONENT REACTION OF 1,1-DICYANO-2-(TRIFLUOROMETHYL)ETHYLENES, PRIMARY ARYLAMINES, AND KETONES

Authors
TYUTIN VY CHKANIKOV ND NESTEROV VN ANTIPIN MY STRUCHKOV YT KOLOMIETS AF FOKIN AV
Citation
Vy. Tyutin et al., A NOVEL 3-COMPONENT REACTION OF 1,1-DICYANO-2-(TRIFLUOROMETHYL)ETHYLENES, PRIMARY ARYLAMINES, AND KETONES, Russian chemical bulletin, 42(3), 1993, pp. 512-521
Citations number
10
Categorie Soggetti
Chemistry
Journal title
Russian chemical bulletin → ACNP
ISSN journal
10665285
Volume
42
Issue
3
Year of publication
1993
Pages
512 - 521
Database
ISI
SICI code
1066-5285(1993)42:3<512:AN3RO1>2.0.ZU;2-R
Abstract
1,1-Dicyano-2,2-bis(trifluoromethyl)ethylene and 3,3-dicyano-2-(triflu oromethyl)acrylates react with primary arylamines in the presence of k etones to form 1,1-aryl-1,4-dihydropyridine derivatives under mild con ditions. The mechanism of this three-component reaction includes the f ormation of Schiff's bases as intermediates. 1,4-Dihydropyridine deriv atives, which are the products of three-component heterocyclization, w ere also obtained by reaction the corresponding Schiff's bases with 1, 1-dicyano-2-(trifluoromethyl)ethylenes.