We report on a patient with a sclerotic fibroma that recurred 30 month
s after initial removal. The histologic features were characteristic,
and immunoperoxidase stains using primary antibodies directed against
cell proliferation markers were positive in a significant proportion o
f the neoplastic nuclei. A review of the literature identified one oth
er sclerotic fibroma that persisted. These clinical and light microsco
pic features support the interpretation that sclerotic fibroma is a pr
oliferating neoplasm with an unusual histologic pattern, rather than t
he end-stage of a process that was formerly more cellular. We advocate
use of sclerotic fibroma as the preferred diagnostic term.