A CASE-REPORT OF DOWN-SYNDROME AND CENTROBLASTIC LYMPHOMA

We describe a case of left cervical stage I centroblastic lymphoma in a 29-year old male patient with Down's syndrome due to a (14; 21) Robe rtsonian translocation. The disease presented as extensive lymph node necrosis leaving rare areas of tumor cells, accounting for the diagnos tic difficulties. According to our review of the literature, lymphoma is one of the most common neoplasms in DS patients and may represent t he second most common malignancy in this condition, far behind leukemi a.