SIGNIFICANCE OF PLATELET MEMBRANE DERANGE MENTS IN VASOSPASTIC ANGINA-PECTORIS DURING ITS EXACERBATION

The parameters of the structure and function of platelet membranes wer e examined in 30 patients with unstable vasospastic angina in relation to the outcome of the disease (myocardial infarction stabilization or development). The fractions of phospholipids (lysophosphatidylcholine , phosphatidylserine, sphingomyelin, phosphatidylcholine, phosphatidyl ethanolamine), the levels of platelet membranous free and esterified c holesterol, plasma malonic dealdehyde and thromboxane B2, the activity of platelet superoxide dismutase and catalase were determined. The ex acerbation of vasospastic angina was found to appear as accumulation o f cholesterol (mainly of its fraction), an increase in platelet membra nous levels of phosphatidylcholine, phosphatidylethanolamine and sphin gomyelin, accumulation of malonic dealdehyde. These changes were more profound in cases with subsequent myocardial infarctions. There were d ifferences in the dynamics of the examined parameters in relation to t he outcome of the disease.