HEMODYNAMIC-EFFECTS OF PURINE NUCLEOSIDES IN REGIONAL ISCHEMIA AND REPERFUSION

The rat hearts were subjected to 60-min ischemia by left coronary arte ry ligation followed by 60-min reperfusion, involving intravenous aden osine, inosine or guanosine given in a dose of 1 mg/kg.min-1 in the fi rst 30 minutes of reperfusion. Ischemia and subsequent reperfusion cau sed a progressive decrease in cardiac output and coronary blood flow. Adenosine was found to enhance coronary blood flow and increase cardia c and stroke outputs. Inosine produced nearly the same, but less prono unced effect. Guanosine increased cardiac output without changing coro nary blood flow.