CLINICAL AND HEMODYNAMIC-EFFECTS OF THE G ABAERGIC STRESS-LIMITING SYSTEM ACTIVATOR SODIUM VALPROATE (ACEDIPROL) AND ETHACIZINE IN PATIENTSWITH CARDIAC-ARRHYTHMIAS

Authors
SKIBITSKY VV MEERSON FZ PETROVA TR MELYUKHOVA NY
Citation
Vv. Skibitsky et al., CLINICAL AND HEMODYNAMIC-EFFECTS OF THE G ABAERGIC STRESS-LIMITING SYSTEM ACTIVATOR SODIUM VALPROATE (ACEDIPROL) AND ETHACIZINE IN PATIENTSWITH CARDIAC-ARRHYTHMIAS, Kardiologia, 32(7-8), 1992, pp. 21-25
Citations number
19
Categorie Soggetti
Cardiac & Cardiovascular System
Journal title
Kardiologia → ACNP
ISSN journal
00229040
Volume
32
Issue
7-8
Year of publication
1992
Pages
21 - 25
Database
ISI
SICI code
0022-9040(1992)32:7-8<21:CAHOTG>2.0.ZU;2-T
Abstract
Hemodynamic and antiarrhythmic effects of acediprol and ethacizine wer e examined in 51 patients with premature ventricular contraction concu rrent with neurocirculatory dystonia and coronary heart disease. It wa s ascertained that acediprol exerted a positive inotropic action and e thacizine lowered myocardial contractility. Acediprol therapy prevents or attenuates the hypokinetic and arrythmogenic effects of stimulated , stress in patients with ischemic and non-ischemic arrhythmias. The p reventive antiarrhythmic effect of acediprol is the most pronounced in patients with neurocirculatory dystonia. Ethacizine fails to improve hemodynamic supply of the stress test and enhances stress-related hypo dynamia in some patients.