EFFECTS OF ANAPRILIN ON SYMPATHOADRENAL R ESPONSIVENESS IN GRADED-EXERCISE IN HEALTHY-INDIVIDUALS AND PATIENTS WITH CORONARY HEART-DISEASE

The specific features of responses of the sympathoadrenal system durin g its activation by graded exercise (E), including that along with ana prilin induced blockade of beta-adrenoceptors, were determined from th e urinary excretion of norepinephrine, epinephrine, dopamine, and diox yphenylalanine in 54 healthy males and 22 patients with postinfarction cardiosclerosis concurrent with Functional Class I-II angina pectoris on effort. E caused hyperreactivity of the sympathoadrenal system, as appeared. as significantly greater increases in the levels of catecho lamines and their precursors in the patients than in the healthy perso ns. A single anaprilin dose of 40 mg abolished the responsiveness to e xercise and improved its tolerance. The revealed features of sympathoa drenal responsiveness to exercise with and without anaprilin suggest t hat the patients with coronary heart disease have sympathoadrenal dysf unction, which shows one of the possible mechanisms responsible for th e cardioprotective effect of beta-adrenoblockers in this disease.