PLATELET VASCULAR HEMOSTASIS IN PATIENTS WITH CORONARY HEART-DISEASE AT REST AND DURING EXERCISE

There was a relationship of the degree of imbalance between thromboxan e and prostacyclin, prostaglandins (PG) F2alpha and E1 in patients wit h coronary heart disease concurrent with stable angina pectoris. A sig nificant increase in the levels of thromboxane and PGF2alpha was found with relative prostacyclin and PGE1 deficiency during graded exercise at the moment of transient myocardial ischemia; the imbalance signifi cantly increased as exercise tolerance decreased. Transient myocardial ischemia induced by transesophageal left atrial pacing revealed unidi rectional changes in plasma PG, as did exercise.