Vi. Kozlovsky et al., EFFECT OF CAPTOPRIL ON TISSUE MICROCIRCUL ATION AND OXYGEN BALANCE INPATIENTS WITH HYPERTENSIVE DISEASE, Kardiologia, 32(6), 1992, pp. 28-29
Bulbar conjunctival microcirculation, aggregation of platelets and red
blood cells, skin oxygen balance were studied in 22 patients with Sta
ge Il hypertensive disease. Captopril was found to decrease not only b
lood pressure, but aggregation of platelets and red blood cells and to
improve tissue oxygen supply. With inadequate doses of the drug, an e
xtreme lowering in blood pressure resulted in deteriorated skin oxygen
supply along with unaltered aggregation of cellular elements.