Mal seco is a grass sickness-like syndrome of horses which has mainly
been observed in Patagonia, Argentina, although some reports indicate
that the disease may exist in other Argentinian provinces and in the s
outh of Chile. The aetiology of mal seco remains unknown but the disea
se seems to be restricted to animals grazing on natural pastures and n
ot receiving supplementary feeding. Mal seco is clinically characteriz
ed by total or partial bowel stasis and the main findings at post-mort
em examination are almost exclusively restricted to the bowel. The mos
t striking histopathological changes found consisted of degenerative c
hanges in the coeliaco-mesenteric ganglia and also in other central an
d peripheral structures of the nervous system.