CHARACTERIZATION AND DECOMPOSITION OF VOLTAGE-ACTIVATED IONIC CURRENTS USING A FITTING NUMERICAL-METHOD

Authors
SZUCS A
Citation
A. Szucs, CHARACTERIZATION AND DECOMPOSITION OF VOLTAGE-ACTIVATED IONIC CURRENTS USING A FITTING NUMERICAL-METHOD, Journal of neuroscience methods, 51(2), 1994, pp. 155-162
Citations number
13
Categorie Soggetti
Neurosciences
Journal title
Journal of neuroscience methods → ACNP
ISSN journal
01650270
Volume
51
Issue
2
Year of publication
1994
Pages
155 - 162
Database
ISI
SICI code
0165-0270(1994)51:2<155:CADOVI>2.0.ZU;2-E
Abstract
The application of a computer-based numerical method for fast determin ation of the kinetic parameters of voltage-activated ionic currents is described. Currents with different kinetics and ionic backgrounds are fitted satisfactorily with Hodgkin-Huxley-like functions, and multico mponent currents are decomposed. The method offers a way to separate i onic-current components without pharmacological isolation.