ACUTE EFFECTS ON BONE-MARROW AFTER ASSOCIATION BETWEEN RADIOSENSITIZER AND X-RAYS - NN N METHOD/

A histopathological and morphometric study was performed in the bone m arrow of mice after association of cisdiamminedi-chloroplatinum II (3. 0 mg/kg) plus X-rays (103.20 mC/kg - 400R). Estimation of bone marrow effects was assessed by counting the number of non nucleated-erythrocy tes (NN) and nucleated (N) cells, and establishing (NN/N) ratio. The m orphomeric method used correlates and makes possible quantification of histopathologic changes of bone marrow through relation of vascular s troma and cellular parenchyma. It can be used as a biological dosimetr y parameter and to estimate injury and recovery of hematologic evoluti on of different myelotoxic agents.