AB-INITIO DIRECT PHASING OF PROTEINS - THE LIMITS

Authors
GIACOVAZZO C GUAGLIARDI A RAVELLI R SILIQI D
Citation
C. Giacovazzo et al., AB-INITIO DIRECT PHASING OF PROTEINS - THE LIMITS, Zeitschrift fur Kristallographie, 209(2), 1994, pp. 136-142
Citations number
22
Categorie Soggetti
Crystallography
Journal title
Zeitschrift fur Kristallographie → ACNP
ISSN journal
00442968
Volume
209
Issue
2
Year of publication
1994
Pages
136 - 142
Database
ISI
SICI code
0044-2968(1994)209:2<136:ADPOP->2.0.ZU;2-B
Abstract
The role of directed methods in the protein field is analyzed. A crite rion is formulated which suggests the necessary conditions for the suc cess or the failure of the ab initio direct procedures. The distributi on of quantity z = [alpha]/sigma(alpha) is central in our consideratio ns. Most of the experimental protein data do not satisfy such a criter ion, therefore their ab-initio solution is a quite improbable event.