Breast artifact occurrence during Tl-201 myocardial image interpretati
on is a significant problem. We serially evaluated 3 female patients u
tilizing exercise treadmill perfusion studies in order to assess the p
otential role of Tc-99m-Sestamibi (MIBI) imaging in the setting of doc
umented Tl-201 breast artifact. Both visual and quantitative analyses
revealed no superiority of Tc-99m-MIBI over Tl-201 imaging in referenc
e to avoidance of breast artifact. The variation in artifactual cardia
c imaging defects in the 3 patients most probably reflected variations
in breast positioning. Finally, the ability to assess ventricular wal
l motion via gated Tc-99m-MIBI imaging may help to confirm an artifact
ual versus an actual myocardial perfusion abnormality.