PATHOGENESIS OF HAEMOPHILUS-PARASUIS INFE CTION OF SWINE (GLASSERS-DISEASE)

Glasser's disease can be experimentally induced with relatively high c ertainty by intraperitoneal and intravenous application of a virulent H. parasuis strain. Intratracheal infection, however, resulted in much lower morbidity, though rates of morbidity were not found to depend o n the quantity of germs injected or number of applications. Morbidity rates were even lower, following intranasal or intratonsillar infectio ns. Evidence was provided to existence of a pneumotropic component of H.parasuis, as was recordable also from herd-related enzootic outbreak s. Clinical manifestation was characterized by strongly pronounced aff inity of the pathogen to serous and synovial membranes.