ISOLATION OF NEW CHLORINATED REGIOISOMERS OF MONO N-SUBSTITUTED URACIL DERIVATIVES AND SYNTHESIS OF 3-SUBSTITUTED YLPYRIMIDO[5,4-E]-1,2,4-TRIAZINE-5,7(6H,8H)-DIONES

Authors
NAGAMATSU T YAMASAKI H YONEDA F
Citation
T. Nagamatsu et al., ISOLATION OF NEW CHLORINATED REGIOISOMERS OF MONO N-SUBSTITUTED URACIL DERIVATIVES AND SYNTHESIS OF 3-SUBSTITUTED YLPYRIMIDO[5,4-E]-1,2,4-TRIAZINE-5,7(6H,8H)-DIONES, Heterocycles, 37(2), 1994, pp. 1147-1164
Citations number
36
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Heterocycles → ACNP
ISSN journal
03855414
Volume
37
Issue
2
Year of publication
1994
Pages
1147 - 1164
Database
ISI
SICI code
0385-5414(1994)37:2<1147:IONCRO>2.0.ZU;2-R
Abstract
A variety of fervenulin type products, 3-substituted ylpyrimido[5,4-e] -1,2,4-triazine-5,7(6H,8H)-diones (18a-i), were synthesized by nitrosa tive or nitrative cyclization of the aldehyde hydrazones (17a-i) deriv ed from 6-(1-methylhydrazino)-1-phenyluracil (16) with aliphatic as we ll as aromatic aldehydes. The compound (16) was prepared by the reacti on of 6-chloro-1-phenyluracil (8) with methylhydrazine. In addition, n ot only the precursor of 16, 6-chloro-1-phenyluracil (8), but also oth er new chlorinated regioisomers of mono N-substituted pyrimidine (9) a nd uracil (14) were isolated and characterized by the reductive dechlo rination of them.