Ne. Cockett et al., CHROMOSOMAL LOCALIZATION OF THE CALLIPYGE GENE IN SHEEP (OVIS-ARIES) USING BOVINE DNA MARKERS, Proceedings of the National Academy of Sciences of the United Statesof America, 91(8), 1994, pp. 3019-3023
A mutation causing muscular hypertrophy, with associated leanness and
improved feed efficiency, has been recently identified in domestic she
ep (Ovis aries). Preliminary results indicate that an autosomal domina
nt gene may be responsible for this economically advantageous trait. W
e have exploited the conservation in sequence and chromosomal location
of DNA markers across Bovidae to map the corresponding callipyge locu
s to ovine chromosome 18 using a battery of bovine chromosome 21 marke
rs. Chromosomal localization of the ovine callipyge locus is the first
step toward positional cloning of the corresponding gene.